Human-in-the-Loop Platform

From Molecule to Market,
Faster, Smarter, Together.

module3 AI unifies process development, quality operations, and regulatory submissions into a single human-in-the-loop platform.

Accelerate Development

Transform promising molecules into approved therapies faster. Our platform cuts document-intensive tasks by up to 70%, shaving weeks off pre-pivotal and pivotal timelines.

Unify Your Workflows

Connect process development, quality assurance, and regulatory compliance in a single environment. No more fragmented tools, disconnected data, or duplicated effort across teams.

Deliver Better Outcomes

Bring life-saving medicines to market more quickly, reduce costs, and maintain the highest standards of compliance, with every AI output reviewed and approved by your SMEs.

FDA 21 CFR Part 11 Ready
EU GMP Annex 11
TLS 1.3 Encryption
Single-Tenant Architecture
Human-in-the-Loop Agents
Immutable Audit Trails
module3.ai / platform / workspace
Workspace
Risk Assessment
Workflows 3
Documents
Analytics
Supplier Mgmt
Root Cause
Agents
CMC Agent
Reg Affairs Agent
QA Agent

IND Amendment: Module 3.2.S

ICH Q11 · 6 parallel agent tracks · SME gate required at each checkpoint

Track 3 of 6 active
🔍
Data Ingestion
37 docs parsed · process records, methods, stability · 0 errors
🧮
Gap Analysis
ICH Q11 compliance · 2 minor gaps flagged · SME reviewed ✓
✍️
Narrative Drafting
§3.2.S.2 + §3.2.S.7 generating · tokens: 4.2k/8k
👤
SME Review Gate
Dr. Patel (CMC) + Dr. Singh (Reg) assigned · e-sig required
🔗
Cross-ref Validation
AI-assisted citation check vs. 37 source docs · SME sign-off required
📤
eCTD Package
Publish-ready XML · all human approvals must be complete
Overall Progress38%
⏱ Est. ~14 min✍ Pending: 3 sections🔒 No auto-submit
● Agent Log
09:14:02 DATA 37 docs indexed
09:14:11 GAP 2 findings
09:14:38 GATE SME sign-off ✓
09:15:02 DRFT §S.2 writing…
📄

Document Harmonization Agent

SOP-MFG-042 Rev.3 · semantic diff · 11 changes proposed · ICH Q11 aligned

Avg. confidence 0.93
➕ 6 additions
➖ 5 removals
📎 3 cited sources
⚡ AI confidence: 0.93
SOP-MFG-042 Rev.2: Current
4.3 Granulation Step

Add purified water (30–35 mL/kg) to the blend. Operate at impeller speed 250 rpm for 8 minutes. Monitor endpoint by power consumption.

Batch yield target: 97.0–100.5%.
Rev.3: AI-Proposed · awaiting SME sign-off
4.3 Granulation Step

Add purified water (28–33 mL/kg) to the blend. Operate at impeller speed 220 rpm for 10 minutes. Monitor endpoint by torque measurement (VM-044).

Batch yield target: 96.5–100.0%.
❆ Aligned with pivotal batch PB-2024-12 · ICH Q11 §3.2.S.2 · ref. BR-2024-031
Top Changes: Agent Rationale
Impeller speed 250220 rpm 0.96 · ref PB-2024-12
Endpoint: powertorque (VM-044) 0.94 · ref AM-2023-09
Mix time: 8 min10 min 0.91 · ref DOE-2024-07
✓ Approve & route for e-sig
✕ Reject selected
⏎ Escalate to senior SME
🔍 All 11 changes
📊

Pipeline Readiness Dashboard

Program MX-401 · Phase II→III · Predictive AI · Live agent telemetry

1 blocker · on-track overall
94%
CMC Readiness
37
Docs AI-Drafted
3
Pending SME Review
⚠ Blocking §S.7 draft
−68%
Time vs. Manual
≈ 6.2 wks saved
Phase Completion + Predicted Close
Process Development100%
Analytical Methods100%
Stability Program81%
Predicted complete: Apr 28
Regulatory Package67%
Predicted complete: May 14 · on track
Agent Telemetry: Last 24h
CMC Agent drafted §3.2.S.2.6 · routed to Dr. Patel · conf 0.97
QA Agent proposed 4 change controls · all pending human review
Reg Agent reconciled 22 CTD refs · 2 flagged for SME · conf 0.89
Blocker T=12M stability pending; §3.2.S.7 gated until results arrive
CMC
QA
Reg
Risk

Risk Assessment Agent

ICH Q9 / FMEA-based scoring · AI confidence-weighted · Human-in-the-loop

2 critical · 5 medium · 18 cleared
ICH Q9 Risk Matrix
LowSeverity →High
2
Critical (RPN ≥ 75)
5
Medium (RPN 40-74)
94%
Compliance Score
0.91
AI Confidence
⚠ CRITICAL: Stability Data Gap
RPN 84 Module 3.2.S.7

T=18M stability time-point unavailable. Predictive model estimates 78% probability of IND delay (6-8 weeks) without accelerated study. Agent recommends parallel accelerated study initiation.

⚡ Escalate to SME
View mitigations
Detectability: 3 · Severity: 4 · Occurrence: 7
⚠ CRITICAL: Supplier GMP Expiry
RPN 78 RM-07 · 18 days

GMP certificate expires in 18 days. Audit overdue 12 days. Cross-checked against 3 alternative qualified suppliers. Supplier E can cover interim supply within 5 business days pending SME approval.

🚫 Procurement hold
🔄 Switch to Supplier E
▲ MEDIUM: OOT Assay Trend
RPN 52 Assay AM-12

3 consecutive results trending −4.2σ/month toward lower spec limit. Predictive model: spec breach in ~9 lots without intervention. Westgard 3×1s rule triggered.

✓ Approve investigation
Defer 30 days
🏭

Supplier Management Agent

12 suppliers · GMP tracking, audit scheduling, procurement risk · HITL

1 critical action required
8
Fully Approved
2
In Qualification
1
Cert Expiring
18d
RM-07 expiry
✅ Supplier A: API Grade Approved
GMP valid Dec 2026 · Audit Mar 2024 ✓
Qual score 88/100 · Single-source API
✅ Supplier B: Excipient Approved
GMP valid Aug 2027 · Audit Jan 2025 ✓
Qual score 76/100 · Dual-qualified
⟳ Supplier C: Packaging In Review
Audit scheduled May 2026 · SME review pending
Qual score 45/100 · Incomplete; 4 docs outstanding
⚠ Supplier D: RM-07 Action Required
GMP cert expires in 18 days · Audit overdue
⚠ Qual score 22/100 · Emergency audit required
Agent Recommendation: Awaiting SME Approval

Initiate emergency audit for Supplier D (RM-07). Agent has pre-identified Supplier E as qualified interim source; can fulfil next PO within 5 business days. Procurement hold recommended until re-cert confirmed. No action executes without SME sign-off.

✓ Approve & initiate audit
🔄 Route PO to Supplier E
📧 Notify procurement
Defer
🔎

Root Cause Analysis Agent

5-Why · Ishikawa · Knowledge Graph traversal · 36mo historical corpus

AI confidence 0.94 · SME review required
🧪 DS-2024-041 · Root Cause Summary
DeviationOOT D(90) 187µm · spec ≤160µm
Root CauseMill speed −12% · sensor drift
Contrib. FactorPM overdue 47d · ML-041
Analogous Events3 · same mill · 36mo corpus
Batch ImpactNon-critical · design space ✓
AI Confidence0.94
Ishikawa · Cause Categories
Equipment
0.85
Process
0.62
Material
0.18
Measurement
0.09
5-Why Chain
D(90) OOT
Mill speed low
Sensor drift
PM overdue 47d ← ROOT
Proposed CAPA Actions: Pending SME Approval
CA-1Re-calibrate mill speed sensor vs. NIST reference standard · 5 business days · owner: Mfg Eng
CA-2Reduce PM interval 600→450 operating hours · update SOP-MFG-031
PA-1Add in-process speed verification every 2 min · update SOP-MFG-034
✓ Approve CAPA & close deviation
✎ Edit proposed actions
📤 Route to QA for e-signature
📋 View 3 analogous events
AI
RCA Agent · just now
Root cause confirmed: mill speed sensor drift (+47d overdue PM). CAPA actions drafted above, ready for your approval before QA routing.
Auto-play walkthrough
0:00
Core capabilities

Everything your team needs in one platform

Workflow Orchestration

Automate and manage complex, multi-step processes across teams and departments, with your team in control at every critical checkpoint.

Knowledge Management

Centralize your data and insights to build a single source of truth: searchable, auditable, and accessible to the right people at the right time.

Human-in-the-Loop AI Agents

Specialized agents that assist with complex tasks, from CMC documentation to regulatory submissions, with your SMEs validating every critical output before it becomes a record.

Document Harmonization

Ensure consistency and quality across all regulatory and clinical documents, with tracked changes reviewed and approved by your team before any revision is finalized.

Data Integration

Connect diverse data sources including manufacturing records, analytical data, and stability studies, to give your team a holistic, real-time view of your entire development pipeline.

Security & Compliance

Single-tenant architecture, TLS 1.3 encryption, MFA, immutable audit logs, and full alignment with FDA 21 CFR Part 11 and EU GMP Annex 11.

Contact us today.

See how validated AI agents can save your team 30% of their work week, across CMC, quality, and regulatory functions.

Get in touch →